Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with SENTINEL FLAVOR TABS. Prior to administration of SENTINEL FLAVOR TABS, dogs should be tested for existing heartworm infections. (See Efficacy).ĭo not use in puppies less than four weeks of age and less than two pounds of body weight. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron has no effect on the adult flea.

Lufenuron's mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron, the other active ingredient in SENTINEL FLAVOR TABS, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm ( Ancylostoma caninum), roundworm ( Toxocara canis and Toxascaris leonina) and whipworm ( Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in SENTINEL FLAVOR TABS, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission.

Sentinel heartworm